PT-2385, CAS 1672665-49-4

Product Description: PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM[1][2].

Applications: Cancer-programmed cell death

Formula: C17H12F3NO4S

References: [1]Eli Wallace, Ph.D. PT2385: HIF-2α Antagonist for the Treatment of VHL Mutant ccRCC. 12th International VHL Medical Symposium April 8, 2016./[2]Xie C, et al. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med. 2017 Nov;23(11):1298-1308./[3]Wallace EM, et al. A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma. Cancer Res. 2016 Sep 15;76(18):5491-500.

CAS Number: 1672665-49-4

Molecular Weight: 383.34

Compound Purity: 99.95

Research Area: Cancer

Solubility: DMSO : ≥ 50 mg/mL

Target: HIF/HIF Prolyl-Hydroxylase

• SKU: MEXHY-12867-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-12867-25
• Package Unit: 25 mg
• Quantity Unit: STK