Target Synonym: MAM;CA 15;MUC;ADMCKD;ADMCKD1;CA 15-3;CD227;EMA;H23AG;KL-6;MAM6;MCD;MCKD;MCKD1;MUC-1;MUC-1/SEC;MUC-1/X;MUC1/ZD;PEM;PEMT;PUM;MUC1;CA15-3;mucin-1;CA15 3;CA153;Episialin;Carcinoma associated mucin;MUC 1;MUC1 beta;MUC1 CT;MUC1 NT;Mucin 1;Peanut reactive urinary mucin;Polymorphic epithelial mucin;Tumor associated mucin;MUC1/CA15-3 C-terminal;EMA;mucin 1;Breast carcinoma-associated antigen DF3;Cancer antigen 15-3;Carcinoma-associated mucin;Krebs von den Lungen-6;Peanut-reactive urinary mucin;Tumor-associated epithelial membrane antigen;Tumor-associated mucin
Background: MUC-1 (Mucin-1; also PEM, PEMT, Episialin, tumor-associated mucin, and carcinoma associated mucin) is a 240-450 kDa type I transmembrane glycoprotein. Human MUC-1 is 1255 amino acids (aa) in length and contains a 23 aa signal sequence, a 1135 aa extracellular domain (ECD), a 23 aa transmembrane segment, and a 74 aa cytoplasmic tail. The ECD consists of degenerate tandem repeats and a tandem repeat region, which makes up the major portion of the protein. Potential O-glycosylation sites (serines and threonines) make up more than one-fourth of the amino acids. Splicing variants produce ten isoforms for human MUC-1. Human MUC-1 is 28% aa identical to Mouse MUC-1.
Immunogen: Recombinant Human CD227 protein
Buffer: PBS, pH 7.2. Contains 0.05% proclin 300.
Dilution: FCM 2 μg/mL(1×105-5×105 cells)
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