Target Synonym: LGP;lysosomal membrane glycoprotein;Lysosome-associated membrane glycoprotein;120 kDa lysosomal membrane glycoprotein;CD107 antigen-like family member A;CD107a;LGP-120;LGP-A;lysosomal membrane glycoprotein 1;Lysosomal membrane glycoprotein A;Lysosome-associated membrane glycoprotein 1;lysosome-associated membrane protein 1;P2B;Lamp-1;Lamp1; LGP-120
Background: CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.
Immunogen: Recombinant Mouse CD107a protein
Buffer: PBS, pH 7.2. Contains 0.05% proclin 300.
Dilution: FCM 2 μg/mL(1×105-5×105 cells)
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