Product Description: Py-MAA-Val-Cit-PAB-MMAE is a drug-Linker conjugates for ADC, which is composed of MMAE (HY-15162) and Py-MAA-Val-Cit-PAB linked. Py-MAA-Val-Cit-PAB-MMAE can be used to synthesize Zapadcine-3a, which targeting TRAILR2. Zapadcine-3a has broad-spectrum anti-tumor activity, and can specifically kill TRAILR2-positive tumors[1][2][3].
Applications: Cancer-programmed cell death
Formula: C72H111N13O16S
References: [1]Zheng Dexia, et al. Anti-tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAILR2) antibody-drug conjugate (ADC) and its pharmaceutical application in antineoplastic therapy: China, CN108452320. 2018-08-28. /[2]Fang, et al. Anti-c-Met antibody drug conjugates and their applications. TWI817190B. 2023.10.01/[3]Fang, et al. Anti-mesothelin antibody and antibody-drug conjugate thereof. WO2019223579A1. 2019-11-28.
CAS Number: 2247398-68-9
Molecular Weight: 1446.79
Compound Purity: 99.78
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Drug-Linker Conjugates for ADC
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