Pyrimidinone 8, CAS 65004-42-4

Product Description: Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM[1].

Applications: Neuroscience-Neuromodulation

Formula: C10H12N4O

References: [1]Montalbetti N, et al. Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2. Biochem Pharmacol. 2015 Aug 1;96(3):216-24.

CAS Number: 65004-42-4

Molecular Weight: 204.23

Research Area: Others

Target: Ferroportin

• SKU: MEXHY-124703-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-124703-0
• Package Unit: Get quote
• Quantity Unit: STK