Product Description: QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker[1].
Applications: Neuroscience-Neuromodulation
Formula: C16H27BrN2O
References: [1]Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114(6):1425-34./[2]Binshtok AM, et al. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology. 2009 Jul;111(1):127-37./[3]Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76(3):2120-4.
CAS Number: 24003-58-5
Molecular Weight: 343.30
Compound Purity: 96.62
Research Area: Neurological Disease
Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 100 mg/mL (ultrasonic)
Target: Sodium Channel
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