Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3,7-dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-1H-purine-2,6-dione
Purity: ≥97%
Formula Markup: C13H20N4O3
Formula Weight: 280.3
CAS Number: 100324-81-0
Notes: LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent.{17416,18148} (R)-LSF is the biologically active isomer of LSF.{17416,18148} It is a potent inhibitor of the generation of phosphatidic acid (IC50 = 0.6 µM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock.{17415} (R)-LSF suppresses the production of the proinflammatory cytokine IFN-γ, inhibits interleukin 12-mediated STAT-4 activation, and enhances glucose-stimulated β-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model.{17414,17416}
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