R112, CAS 575474-82-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-phenol

Purity: ≥98%

Formula Markup: C16H13FN4O2

Formula Weight: 312.3

CAS Number: 575474-82-7

Notes: R112 is an inhibitor of spleen tyrosine kinase (Syk; IC50 = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (Ki = 96 nM).{46184} It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC50s = 353 and 280 nM, respectively). It also inhibits basophil degranulation induced by an allergen with an EC50 value of 490 nM. R112 inhibits the production of leukotriene C4 (LTC4; Item No. 20210) and decreases cytokine levels in cultured human mast cells.

• SKU: CAY22929-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22929-5
• Package Unit: 5 mg
• Quantity Unit: STK