R1487 (hydrochloride), CAS 449808-64-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 6-(2,4-difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-pyrido[2,3-d]pyrimidin-7(8H)-one, monohydrochloride

Purity: ≥98%

Formula Markup: C19H18F2N4O3 / HCl

Formula Weight: 424.828826

CAS Number: 449808-64-4

Notes: R1487 is an inhibitor of p38α MAPK (IC50 = 10 nM).{33190} It is selective for p38α over p38β MAPK (Kds = 0.2 and 29 nM, respectively), as well as a panel of 306 additional kinases at 10 µM, but does inhibit 11 kinases by greater than 85% at 10 µM. R1487 inhibits LPS-induced IL-1β production in isolated human whole blood (IC50 = 170 nM). It also inhibits LPS-induced production of TNF-α and IL-6 in rats (ED50s = 0.8 and 0.4 mg/kg). R1487 reduces yeast-induced hyperalgesia in rats (ED50 = 5.5 mg/kg).

• SKU: CAY31478-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 31478-1
• Package Unit: 1 mg
• Quantity Unit: STK