Rabbit anti-Astrin/MAP126 Antibody Affinity Purified

Stock Concentration: 200 µg/ml

Conjugate Type: Unconjugated

Buffer: Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide

Shelf Life: 1 year from date of receipt

Protein Ref Seq ID: NP_006452.3

Uniprot ID: Q96R06

Background: Astrin/MAP126 has been identified as a mitotic spindle-associated protein essential for centrosome integrity and the progression through mitosis. Astrin/MAP126 interacts with Ninein and Aurora-A at the centrosome. Ninein, but not Aurora-A, appears to be required for proper localization of Astrin/MAP126 to the centrosome during S and G2 phase. A pool of Astrin/MAP126 also localizes to the outer kinetochore where it plays an essential role in chromatid adhesion and chromosome congression and segregation. The localization of Astrin/MAP126 to the spindle pole and kinetochore has been shown to be dependent on its phosphorylation by glycogen synthase kinase 3beta (GSK3beta).

Immunogen: Between 900 and 950

Physical State: Liquid

Purity: Antigen Affinity Purified

Antibody Registry ID: AB_999600

• SKU: BEYA301-512A
• Manufacturer: Bethyl Laboratories
• Manufacturer SKU: A301-512A
• Package Unit: 100 µl
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Polyclonal
• Application: Immunoprecipitation, Western Blotting
• Isotype: IgG
• Human Gene ID: 10615
• Host: Rabbit
• Conjugate: Unconjugated