Background: KLF14 is a member of the KrŸppel-like factor family of transcription factors. It regulates the transcription of various genes, including TGF RII (the type II receptor for TGF ). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression.
Positive Control: Human tonsil.
Immunogen: Synthetic peptide derived from the human KLF14 protein.
Purification Method: Antigen Immunoaffiinity Purification.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Truty, M.J., et al. ‘Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling.’ J. Biol. Chem., 284, 6291-6300 (2009)
2. Swamynathan, S.K. ‘Krüppel-like factors: three fingers in control.’ Hum. Genomics, 4, 263-270 (2010)
3. Parker-Katiraee, L., et al. ‘Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution.’ PLoS Genet., 3, e65, (2007).
UniProt: Q8TD94.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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