Background: Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.
Positive Control: Human testis.
Immunogen: Synthetic peptide derived from the human SALL4 protein.
Purification Method: Antigen Immunoaffiinity Purification.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Ma, Y., et al. ‘SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice.’ Blood, 108, 2726-2735 (2006)
2. Kohlhase, J., et al. ‘Okihiro syndrome is caused by SALL4 mutations.’ Hum. Mol. Genet., 11, 2979-2987 (2002)
3. Yang, F., et al. ‘Sumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor.’ J. Biol. Chem., 287, 38600-38608 (2012).
UniProt: Q9UJQ4.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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