Stock Concentration: 1000 µg/ml
Conjugate Type: Unconjugated
Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Shelf Life: 1 year from date of receipt
Protein Ref Seq ID: NP_056128.1
Uniprot ID: Q9NZN5
Background: LARG (leukemia-associated RhoGEF) is homologous to PDZ-RhoGEF and functions as a RhoA-specific guanine nucleotide exchange factor. RhoGEFs catalyze the exchange of GDP for GTP on the GTPase, Rho, to activate downstream signaling pathways. LARG contains a PDZ [post synaptic density protein (PSD95), Drosophila discs-large tumor suppressor (DIgA), and zonula occludens-1 protein (zo-1)] domain which is an 80-90 amino acid structural domain found in signaling proteins in bacteria, yeast, plants, and animals. LARG is proposed to play a role in cell polarity and microtubule dynamics and may act as a GTPase-activating protein (GAP) for the heterotrimeric Galpha(12) and Galpha(13) proteins.
Immunogen: Between 1494 and C-terminus
Physical State: Liquid
Formulation: BSA-Free
Purity: Antigen Affinity Purified
Antibody Registry ID: AB_1547963
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