Rabbit anti-MDC1 Polyclonal Antibody

Stock Concentration: 1000 µg/ml

Conjugate Type: Unconjugated

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Shelf Life: 1 year from date of receipt

Protein Ref Seq ID: NP_055456.1

Uniprot ID: Q14676

Background: Mediator of DNA damage checkpoint protein 1 (Mdc1) is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It may serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. It is also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5PSV9].

Immunogen: Between 925 and 975

Physical State: Liquid

Formulation: BSA-Free

Purity: Antigen Affinity Purified

Antibody Registry ID: AB_203283

• SKU: BEYA300-052A-T
• Manufacturer: Bethyl Laboratories
• Manufacturer SKU: A300-052A-T
• Package Unit: 10 µl (1000 µg/ml)
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Polyclonal
• Application: Immunoprecipitation, Western Blotting, Immunohistochemistry
• Isotype: IgG
• Human Gene ID: 9656
• Host: Rabbit
• Conjugate: Unconjugated