Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[(4-fluorophenyl-d4)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-4-pyrimidinecarboxamide
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C20H17D4FN6O5
Formula Weight: 448.440823
CAS Number: 2712343-38-7
Notes: Raltegravir-d4 is intended for use as an internal standard for the quantification of raltegravir (Item No. 16071) by GC- or LC-MS. Raltegravir is an orally bioavailable inhibitor of HIV-1 integrase (IC50 = 15 nM in a strand transfer assay).{26192} It inhibits the spread of HIV-1IIIb infection in MT-4 cell culture with 95% cell culture inhibitory concentration (CIC95) values of 19 and 31 nM in medium containing 10% heat-inactivated fetal bovine serum (FBS) or 50% normal human serum, respectively. Formulations containing raltegravir have been used in combination therapy in the treatment of HIV-1 infection.
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