Notes: Ramipril is a prodrug form of the angiotensin-converting enzyme (ACE) inhibitor ramiprilat (Item No. 15557).{23056} Ramipril (2.5 mg/kg per day, p.o.) reduces systolic blood pressure in spontaneously hypertensive rats.{36825} It reduces aortic valve backscatter and improves aortic flow in a rabbit model of aortic valve stenosis.{36826} Ramipril also decreases paw swelling and serum levels of TNF-α and prostaglandin E2 (PGE2) as well as cardiac collagen deposition and fibrosis in a rat model of adjuvant-induced arthritis.{36827}