Rapamycin-d3, CAS 392711-19-2

Shelf life (days): 365.0

Formulation: A solution in ethanol

Formal Name: 7-O-demethyl-7-O-(methyl-d3)-rapamycin

Purity: ≥98% deuterated forms (d1-d3)

Formula Markup: C51H76D3NO13

Formula Weight: 917.2

CAS Number: 392711-19-2

Notes: Rapamycin-d3 is intended for use as an internal standard for the quantification of rapamycin (Item No. 13346) by GC- or LC-MS. Rapamycin is an allosteric inhibitor of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1).{45403} It interacts with FKBP prolyl isomerase 1A (FKBP12) to form a complex that binds to and inhibits the kinase activity of mTORC1. Rapamycin inhibits growth of Rh1 and Rh30 rhabdomyosarcoma cells in serum-free medium, with 50% inhibition observed at concentrations of 0.1 and 0.5 ng/ml, respectively, and increases apoptosis in these cells at 100 ng/ml.{45404} It also induces autophagy in a variety of cell types.{45403} Rapamycin inhibits IL-2-induced proliferation of IL-2-dependent T cells by 50% when used at concentrations less than 5 pM.{17469} Formulations containing rapamycin have been used as immunosuppressive agents in the prevention of organ transplant rejection.

• SKU: CAY22093-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22093-500
• Package Unit: 500 µg
• Quantity Unit: STK
• Application: GC-MS, LC-MS, Isotopenmarkierung