Target Synonym: RET;PRO;Retinol-binding protein;MCOPCB;RBP4;MCOPCB10;RDCCAS;RBP-4;RET4;PRBP;RBP;Retinol-binding protein 4;Plasma retinol-binding protein;Cleaved into Plasma retinol-binding protein;Plasma retinol-binding protein 1-181;Plasma retinol-binding protein 1-179;Plasma retinol-binding protein(1-176);PRO2222
Background: Retinol (also known as vitamin A) is unstable and insoluble in the aqueous solution. However, retinol becomes quite stable and soluble in plasma due to its tight interaction with retinol-binding protein 4 (RBP4), also known as plasma retinol-binding protein. A prototypic member of the lipocalin superfamily, RBP4 has a beta -barrel structure with a well-defined cavity. It is secreted from the liver, a process requiring the availability of retinol. RBP4 delivers retinol from the liver to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), also known as thyroxine-binding protein and prealbumin. The retinol-RBP4-TTR complex prevents the loss of RBP4 by filtration through the kidney and increases the stability of the retinol-RBP4 complex. Defects in RBP4 cause retinol-binding protein deficiency, which affects night vision.
Immunogen: Recombinant Human RBP4 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:50-1:200;
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