Recombinant Human CD30L Protein(Fc Tag)

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Protein Tag: C-Fc

Uniprot: P32971

Accession: P32971

Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin"s and some non-Hodgkin"s lymphomas. Two transcript variants encoding different isoforms have been found for this gene.

Bio Acitivity: Not validated for activity

Sequence: Gln63-Asp234

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW: 43.8 kDa

Observed MW: 50-70 kDa

• SKU: ELSPDMH100218-1
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: PDMH100218-1
• Package Unit: 1 mg
• Quantity Unit: STK