Recombinant Human CD40 Protein(His Tag)

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Protein Tag: C-His

Uniprot: P25942

Accession: P25942

Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

Bio Acitivity: Not validated for activity

Sequence: Glu21-Arg193

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW: 18.9 kDa

Observed MW: 25-35 kDa

• SKU: ELSPDMH100223-1
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: PDMH100223-1
• Package Unit: 1 mg
• Quantity Unit: STK