Target Synonym: Fibroblast growth factor-binding protein 2
Background: FGFBP2 (Fibroblast Growth Factor Binding Protein 2), a secreted chaperone, regulates fibroblast growth factors (FGFs)—key signaling molecules critical for tissue repair, angiogenesis, and cell proliferation—by binding specific ligands (e.g., FGF-1, FGF-2) through a conserved domain to enhance their release from extracellular storage or receptor interactions. Primarily expressed in regenerative or metabolically active tissues (e.g., liver, kidney, epithelia), FGFBP2 is tightly controlled under normal conditions but often overexpressed in cancers, where it amplifies FGF-driven tumor progression by promoting angiogenesis, survival, and metastasis, while also being implicated in metabolic disorders and inflammation through potential links to insulin resistance and fibrosis. Though functionally overlapping with its paralog FGFBP1, FGFBP2 exhibits distinct tissue-specific expression and ligand preferences, with ongoing research focused on elucidating its mechanistic roles in FGF signaling and exploring its therapeutic or biomarker potential in cancer and FGF-associated diseases.
Bio Activity: Not validated for activity
Sequence: Gln20-Gly223
Purity: > 85% as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Calculated MW: 37.33 kDa
Observed MW: 40 kDa
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