Recombinant Human LRG1 Protein(His Tag)

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Protein Tag: C-His

Uniprot: P02750

Accession: P02750

Background: LRG1 (Leucine-Rich Alpha-2-Glycoprotein 1) is a Protein Coding gene. LRG1 belongs to the leucine-rich repeat (LRR) family. Members of this family are involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation. It contains 4 LIM zinc-binding domains and 1 Rho-GAP domain. LRG1 is involved in promoting neovascularization (new blood vessel growth) by causing a switch in transforming growth factor-beta (TGFbeta) signaling in endothelial cells. LRG1 binds to the accessory receptor endoglin and promotes signaling via the ALK1-Smad1/5/8 pathway. It may be a potential therapeutic target for the treatment of diseases where there is aberrant neovascularization. Diseases associated with LRG1 include Appendicitis and Normal Pressure Hydrocephalus.

Bio Acitivity: Not validated for activity

Sequence: Met1-Gln347

Purity: > 85% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method

Calculated MW: 38.0 kDa

Observed MW: 43 kDa

• SKU: ELSPDMH100450-20
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: PDMH100450-20
• Package Unit: 20μg
• Quantity Unit: STK