Recombinant Human FKBP3/FKBP25 Protein (His Tag)

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Protein Tag: N-His

Uniprot: Q00688

Accession: Q00688

Background: FKBP25 contains 1 PPIase FKBP-type domain; belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin; as well as histone deacetylases; the transcription factor YY1; casein kinase II; and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.

Bio Acitivity: Not validated for activity

Sequence: Met 1-Asp224

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM DTT, 10% Glycerol, pH 8.0.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 27.3 kDa

Observed MW: 30 kDa

• SKU: ELSPKSH032876-50
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: PKSH032876-50
• Package Unit: 50μg
• Quantity Unit: STK