Recombinant Human THAP1 protein(His tag)

Protein Tag: N-His

Uniprot: Q9NVV9

Accession: Q9NVV9

Background: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.

Bio Acitivity: Not validated for activity

Sequence: Met1-Phe81

Purity: > 80% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin: < 10 EU/mg of the protein as determined by the LAL method.

Calculated MW: 9.5 kDa

Observed MW: 11 kDa

• SKU: ELSPDEH100767-1
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: PDEH100767-1
• Package Unit: 1mg
• Quantity Unit: STK
• Reactivity: Human
• Host: Escherichia Coli