Recombinant Human TLR2 Protein(His Tag)

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Protein Tag: C-His

Uniprot: O60603

Accession: O60603

Background: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.

Bio Acitivity: Not validated for activity

Sequence: Glu21-Leu590

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method.

Calculated MW: 62.5 kDa

Observed MW: 70-80 kDa

• SKU: ELSPDMH100206-1
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: PDMH100206-1
• Package Unit: 1 mg
• Quantity Unit: STK