Target Synonym: Type I interferon receptor;Interferon alpha/beta receptor;IFN-R-1 IFN-alpha/beta receptor;Cytokine receptor class-II member;Cytokine receptor family 2 member;CRF2;CRF2-1;Cytokine receptor class-II member 1;Cytokine receptor family 2 member 1;IFN-R-1 IFN-alpha/beta receptor 1;Interferon alpha/beta receptor 1;Type I interferon receptor 1;Ifar;Ifnar;Ifnar1;Alpha type antiviral protein;alpha-type;Antiviral protein;AVP;Beta type antiviral protein;beta-type;CD118;IFN alpha REC;IFN alpha receptor;IFN alpha/beta Receptor alpha;IFN beta receptor;IFN Interferon-beta receptor;IFN-alpha/beta receptor 1;IFNBR;IFN-R-1;IFRC;INAR1;Infar;Interferon (alpha beta and omega) receptor 1;interferon alpha and beta receptor subunit 1;Interferon alpha/beta receptor alpha chain;Interferon beta receptor 1;interferon receptor 1;Interferon-alpha receptor
Background: Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
Immunogen: Recombinant Mouse IFNAR1 Protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: ICC/IF 1:20-1:100
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