Target Synonym: UNQ;PRO;ATAG;KIAA;RP11 517F;Anterior pharynx defective;RP11517F;NCSTN;ATAG1874;nicastrin;Anterior pharynx defective 2;APH 2;APH2;NCT;NICA;RP11 517F10.1;RP11517F101;KIAA0253;UNQ1874;PRO4317;RP11-517F10.1
Background: This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Immunogen: Recombinant Human Nicastrin/NCSTN protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:1000;IP 0.2-1 μL/mg of lysate
Calculated MW: 78 kDa
Observed MW: 170 kDa
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