Target Synonym: MEK;MKK;CFC;MAPKK;PRKMK;MAP2K;CFC3;MAPKK1;MEK1;MKK1;PRKMK1;MAP2K1;Dual specificity mitogen activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 1;ERK activator kinase 1;kinase 1;MAP kinase kinase 1;MAP kinase/Erk kinase 1;MAPK/ERK kinase 1;MAPKK 1;MEK 1;MEKK1;Mitogen activated protein kinase kinase 1;MKK 1;MP2K1;Protein kinase mitogen activated;Protein kinase mitogen activated kinase 1 (MAP kinase kinase 1)
Background: The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
Immunogen: A synthetic phosphopeptide corresponding to residues around Ser218 and Ser222 of the Human MEK1
Buffer: 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5
Dilution: WB 1:2000-1:20000
Calculated MW: 43 kDa
Observed MW: 43 kDa
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