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Protein Tag: N-His & C-His
Uniprot: P16573
Accession: P16573
Background: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation-and PTPN6-dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors.Plays a role in immune response, of T-cells, natural killer (NK) and neutrophils.
Bio Acitivity: Not validated for activity
Sequence: Gln35-Ala425
Purity: > 90% as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Endotoxin: < 10 EU/mg of the protein as determined by the LAL method.
Calculated MW: 45.1 kDa
Observed MW: 40-50 kDa
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