Recombinant Rat TNF-α Protein(hIgG1 Fc Tag)

Target Synonym: Tumor Necrosis Factor;TNF;TNFA

Background: Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.

Bio Activity: Not validated for activity

Sequence: Leu80-Leu235

Purity: > 80% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Calculated MW: 42.0 kDa

Observed MW: 45 kDa

• SKU: ELSPDMR100107-1
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: PDMR100107-1
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Rat (Rattus)