Recombinant SNCA/alpha-Synuclein Monoclonal Antibody

Target Synonym: Fetal liver kinase;Protein-tyrosine kinase receptor flk;Vascular endothelial growth factor receptor;PD1;NACP;PARK1;PARK4;SNCA;SNC-A;aSYN;CD309;Fetal liver kinase 1;FLK1;FLK-1;KDR;Kinase insert domain receptor;Protein-tyrosine kinase receptor flk-1;Vascular endothelial growth factor receptor 2;VEGFR;VEGFR2;VEGFR-2;Alpha-synuclein;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;PARK1;alpha (non A4 component of amyloid precursor);Alpha synuclein;alphaSYN;isoform NACP140;Lewy body) 4;MGC105443;MGC110988;MGC127560;MGC64356;Non A beta component of AD amyloid;Non A4 component of amyloid;Non A4 component of amyloid precursor;Non-A4 component of amyloid;Non-A-beta component of alzheimers disease amyloid;OTTHUMP00000218549;OTTHUMP00000218551;OTTHUMP00000218552;OTTHUMP00000218553;OTTHUMP00000218554;PARK 1;PARK 4;Parkinson disease (autosomal dominant;Parkinson disease familial 1;precursor of;Snca synuclein;SYN;Synuclein;Synuclein alpha;Synuclein alpha 140;SYUA

Background: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

Immunogen: Recombinant Human SNCA/alpha-Synuclein protein

Buffer: 0.2 μm filtered solution in PBS

Dilution: WB 1:500-1:2000

Calculated MW: 16 kDa

Observed MW: 18 kDa

• SKU: ELSAN300413P-100
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: AN300413P-100
• Package Unit: 100μL
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: Western Blotting
• Isotype: IgG
• Host: Rabbit
• Conjugate: Unconjugated