Product Description: Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets Thrombin. Ichorcumab binds to exosite 1 on thrombin and inhibits substrate binding but not catalytic activity. The isotype control for Ichorcumab can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003)[1].
Applications: Neuroscience-Neuromodulation
Formula: N/A
References: [1]Weitz JI, et al. Randomized phase 2 trial comparing JNJ-9375, a thrombin-directed antibody, with apixaban for prevention of venous thrombosis. J Thromb Haemost. 2019 Dec;17(12):2081-2088.
CAS Number: 2589583-20-8
Molecular Weight: N/A
Research Area: Cardiovascular Disease
Target: Thrombin