MP-RM-1

Product Description: MP-RM-1 is a selective murine monoclonal antibody inhibitor targeting human epidermal growth factor receptor 3 (ErbB-3). MP-RM-1 blocks the activation of ErbB-3 induced by neuregulin 1 (NRG-1β) and promotes the internalization and degradation of ErbB-3, inhibiting downstream signaling pathways such as PI3K-Akt. MP-RM-1 is promising for research of ErbB-3 highly expressed solid tumors such as breast cancer, melanoma, and prostate cancer[1].

Applications: Cancer-Kinase/protease

Formula: N/A

References: [1]Sala G, et al. An ErbB-3 antibody, MP-RM-1, inhibits tumor growth by blocking ligand-dependent and independent activation of ErbB-3/Akt signaling. Oncogene. 2012 Mar 8;31(10):1275-86.

Molecular Weight: N/A

Research Area: Cancer

Target: Akt;EGFR;PI3K

• SKU: MEXHY-P991243-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P991243-0
• Package Unit: Get quote
• Quantity Unit: STK
• Conjugate: Unconjugated