Clone Name: BCL6/1718
Light Chain: Kappa
Application Note: IHC-P: 1-2μg/ml for 30 minutes at RT. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 79
Form: Liquid
Buffer (with preservative): 10mM PBS, 0.05% BSA, 0.05% Sodium azide.
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot ID: P41182
Antigen Species: Human
Immunogen: Recombinant human bcl-6 protein fragment (aa256-389) (exact sequence is proprietary)
Purification: Protein A/G purified
Conjugation: Unconjugated
Full Name: BCL6 transcription repressor
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