Clone Name: MEM-154
Calculated MW: 29
Specificity/Sensitivity: This antibody reacts with an epitope on CD16 antigen that is residing in proximity to FG loop (probably BC or C'E loop).
Form: Liquid
Buffer (with preservative): 0.2μm filter-sterilized PBS, no preservative.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot ID: P08637
Antigen Species: Human
Immunogen: Human granulocytes
Purification: Protein A purified
Conjugation: Unconjugated
Full Name: Fc fragment of IgG receptor IIIa
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