Clone Name: MEM-53
Calculated MW: 24
Specificity/Sensitivity: This antibody reacts with CD53, a 32-40 kDa tetraspanin family glycoprotein exclusivelly expressed on leukocytes. And this antibody also reacts with deglycosylated molecule (molecular weight of the antigen is reduced by 15 kDa using endoglycosidase F).
Form: Liquid
Buffer (with preservative): 0.2μm filter-sterilized PBS, no preservative.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot ID: P19397
Antigen Species: Human
Immunogen: Leukocytes of pacient suffering from a LGL-type leukemia.
Purification: Protein A purified
Conjugation: Unconjugated
Full Name: CD53 molecule
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