Clone Name: GZMB/2403
Light Chain: Kappa
Application Note: ELISA: 1-5μg/ml (for coating). *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 28
Form: Liquid
Buffer (with preservative): 10mM PBS, 0.05% BSA, 0.05% Sodium azide.
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
Uniprot ID: P10144
Antigen Species: Human
Immunogen: Recombinant fragment of human GZMB protein (around aa 73-187) (exact sequence is proprietary)
Purification: Protein A/G purified
Conjugation: Unconjugated
Full Name: granzyme B
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