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Application: Useful for ELISA, flow cytometry and functional assays.
Background: TSLP (thymic stromal lymphopoietin) is a protein that functions as a type I cytokine, as an alarmin and growth factor in the immune system. It is involved in type 2 immune responses, TH2 (T helper 2 cells) responses, and the maturation and recruitment of dendritic cells (DCs), T cells, B cells, neutrophils, mast cells, and other lymphoid cells. It can be produced by epithelial and stromal cells in lung, skin, and gastric system, but also by DCs, basophils and mast cells. Its expression can be induced by infections, pro-inflammatory cytokines, proteases, and even mechanical injury. For instance, it can be produced in the lungs in response to infection with influenza or rhinovirus. Its role as alarmin can result in increasing inflammation. TSLP is linked to allergic reactions, such as asthma, atopic dermatitis, and food allergies, by inducing the expression of OX40L, CD80 and CD86 and stimulating CD4+ T cells. In 2021, the TLSP-neutralizing antibody tezepelumab was approved for the treatment of severe asthma. Targeting TSLP is an active area of investigation with ongoing clinical trials for the treatment of autoimmune disorders. Lunsekimig is currently being investigated for the threatment of asthma, and chronic rhinosinusitis,
Clone Number: Monoclonal
Description: Lunsekimig is an monoclonal antibody targeting TSLP, IL-13, and albumin composed of 5 sequentially linked variable region heavy chains. This antibody was affinity purified.
Format: Aqueous buffer solution.
Formulation: Supplied as a 0.22 μm filtered solution in PBS, pH 7.2.
Purity: ≥90% by SEC-HPLC.
Reconstitution: The product can be reconstituted/diluted with sterile PBS or saline.
Storage Stability: Store at -80°C for 2 years. Aliquots should be stored at the same temperature after first use to avoidmultiple freeze-thaws cycles.
Target: IL-13, TSLP
Uniprot: Q969D9 (TSLP), P35225 (IL-13) and P02768 (Albumin)
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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