Target Synonym: SKR;ORW;Activin Receptor-Like Kinase;Serine/Threonine-Protein Kinase Receptor R;ACVRL;ACVRLK;ALK;ACVRL1;ACVRLK1;ALK-1;ALK1;HHT;HHT2;ORW2;SKR3;TSR-I;Activin Receptor-Like Kinase 1;Serine/Threonine-Protein Kinase Receptor R3;TGF-B Superfamily Receptor Type I
Background: This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Immunogen: Recombinant Human ALK-1 / ACVRL1 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:2000;IP 1-4 μL/mg of lysate
Calculated MW: 56 kDa
Observed MW: 41 kDa
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