Recombinant Bcl-2 Monoclonal Antibody

Target Synonym: B-cell Lymphoma;PPP1R;BCL;Bcl-2;PPP1R50;BCL2;apoptosis regulator Bcl-2;B-cell Lymphoma 2;apoptosis regulator Bcl-2;Bcl-2;PPP1R50;Apoptosis regulator Bcl 2;Apoptosis regulator Bcl2;AW986256;B cell CLL/lymphoma 2;B cell leukemia/lymphoma 2;B-cell;C430015F12Rik;D630044D05Rik;D830018M01Rik;Leukemia/lymphoma;Oncogene B-cell leukemia 2;Protein phosphatase 1;regulatory subunit 50;Bcl2

Background: Bcl-2 is a member of a family of proteins that regulates outer mitochondrial membrane permeability. Bcl-2 is an anti-apoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Bcl-2 is present on the outer mitochondrial membrane and is also found on other membranes in some cell types. Natural Bcl-2 contains a carboxyl-terminal mitochondria targeting sequence. Recombinant Bcl-2, missing the mitochondrial targeting sequence, maintains its ability to neutralize pro-apoptotic Bcl-2 family members. Neutralization by Bcl-2 appears to be through binding the BH3 region of pro-apoptotic Bcl-2 family members. This activity does not require the mitochondrial targeting sequence.

Immunogen: A synthetic peptide corresponding to the N-terminus of the Human Bcl-2.

Buffer: 0.2 μm filtered solution in PBS

Dilution: IHC-P 1:250-1:1000;FCM 1:25-1:100;

• SKU: ELSAN300032P-100
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: AN300032P-100
• Package Unit: 100μL
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: Immunohistochemistry (paraffin), Flow Cytometry
• Isotype: IgG
• Host: Rabbit
• Conjugate: Unconjugated