Target Synonym: CA9;CAIX;MN;CA-IX;Carbonate dehydratase IX;Carbonic Anhydrase IX;Carbonic Dehydratase;P54/58N;RCC;RCC-Associated Protein G250;G250;CAH9;Carbonic anhydrase 9;Membrane antigen MN;pMW1;RCC associated protein G250;RCC-associated antigen G250;Renal cell carcinoma-associated antigen G250
Background: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
Immunogen: Recombinant Human Carbonic Anhydrase IX / CA9 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:250-1:1000;
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