Target Synonym: NQO;DIA;NMOR;DHQU;DIA4;DTD;NMOR1;NMORI;QR1;NQO1;Azoreductase;Cytochrome b 5 reductase;DIA 4;Diaphorase (NADH/NADPH);Diaphorase (NADH/NADPH) (cytochrome b 5 reductase);Diaphorase 4;Dioxin inducible 1;DT diaphorase;DT-diaphorase;Menadione reductase;NAD(P)H dehydrogenase [quinone] 1;NAD(P)H dehydrogenase quinone 1;NAD(P)H menadione oxidoreductase 1 dioxin inducible;NAD(P)H quinone dehydrogenase 1;NAD(P)H: menadione oxidoreductase 1 dioxin inducible 1;NAD(P)H:menadione oxidoreductase 1;NAD(P)H:Quinone acceptor oxidoreductase type 1;NAD(P)H:quinone oxidoreductase 1;NAD(P)H:quinone oxireductase;NMOR 1;NMOR I;NQO 1;Phylloquinone reductase;QR 1;Quinone reductase 1
Background: This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 1-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Immunogen: Recombinant Human NQO1 Protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:2000;
Calculated MW: 31 kDa
Observed MW: 31 kDa
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