Target Synonym: IFI;PSME;PSME1;HEL-S-129m;IFI5111;PA28A;PA28alpha;REGalpha;macropain) activator subunit 1 (PA28 alpha);11S regulator complex alpha subunit;11S regulator complex subunit alpha;29 kD MCP activator subunit;29kD MCP activator subunit;Activator of multicatalytic protease subunit 1;IGUP I-5111;Interferon gamma IEF SSP 5111;Interferon gamma inducible protein 5111;Interferon gamma up regulated I 5111 protein;Interferon gamma up-regulated I-5111 protein;MGC8628;Proteasome (prosome;Proteasome activator 28 subunit alpha;Proteasome activator complex subunit 1;Proteasome activator subunit 1;REG-alpha
Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 8S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants.
Immunogen: Recombinant Human PA28A / PSME1 Protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:2000;
Calculated MW: 29 kDa
Observed MW: 33 kDa
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