Target Synonym: CDC;CDK;CDKN;cyclin-dependent kinase;P34CDC;CDK1;CDC2;CDC28A;P34CDC2;cyclin-dependent kinase 1;CDKN1;CDC2;CDC28A;cyclin-dependent kinase 1;P34CDC2;cyclin dependent kinase 1874
Background: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Immunogen: A synthetic phosphopeptide corresponding to residues around Tyr15 of the Human cdc2
Buffer: 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5
Dilution: WB 1:5000-1:50000;
Calculated MW: 34 kDa
Observed MW: 34 kDa
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