Target Synonym: HGNC;CRKL;Crk L;Crk like protein;Crk-like protein;Crkol;HGNC:2363;Oncogene CrkL;V crk avian sarcoma virus CT10 oncogene homolog like;v crk sarcoma virus CT10 oncogene homolog (avian) like;V crk sarcoma virus CT10 oncogene homolog avian like;HGNC:2363
Background: This gene encodes a protein kinase containing SH2 and SH0 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
Immunogen: A synthetic peptide corresponding to the residues around (Tyr207) of Human Phospho-CrkL
Buffer: 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5
Dilution: WB 1:1000-1:5000;
Calculated MW: 35 kDa
Observed MW: 38 kDa
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