Target Synonym: EIF2S;EIF;EIF-2;EIF-2A;EIF-2alpha;EIF2;EIF2A;EIF2S1;EIF 2;EIF 2 alpha;EIF 2A;EIF 2alpha;EIF2 alpha;eIF-2-alpha;Eukaryotic translation initiation factor 2 subunit 1;Eukaryotic translation initiation factor 2 subunit 1 alpha;Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa;Eukaryotic translation initiation factor 2 subunit alpha;IF2A
Background: The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2007]
Immunogen: A synthetic phosphopeptide corresponding to residues around Ser51 of human Phospho-eIF2α.
Buffer: 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5
Dilution: WB 1:1000-1:10000;
Calculated MW: 36 kDa
Observed MW: 36 kDa
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