Target Synonym: RAFT;RAPT;FK506 binding protein 12-rapamycin associated protein;FRAP;FRAP1;FRAP2;RAFT1;RAPT1;SKS;mTOR;FK506 binding protein 12-rapamycin associated protein 1;Mechanistic target of rapamycin;dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1);FK506 binding protein 12 rapamycin associated protein 1;FK506 binding protein 12 rapamycin associated protein 2;FK506 binding protein 12 rapamycin complex associated protein 1;FK506-binding protein 12-rapamycin complex-associated protein 1;FKBP rapamycin associated protein;FKBP12 rapamycin complex associated protein;FKBP12-rapamycin complex-associated protein;FKBP12-rapamycin complex-associated protein 1;FLJ44809;Mammalian target of rapamycin;OTTHUMP00000001983;Rapamycin and FKBP12 target 1;Rapamycin associated protein FRAP2;Rapamycin target protein;Rapamycin target protein 1;Serine/threonine-protein kinase mTOR
Background: The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
Immunogen: A synthetic peptide corresponding to the residues around Ser2448 of Human Phospho-mTOR
Buffer: 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5
Dilution: WB 1:2000-1:20000;
Calculated MW: 280 kDa
Observed MW: 288 kDa
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