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Application: USeful for ELISA, flow cytometry and functional assays.
Background: B-lymphocyte antigen CD19 (Cluster of Differentiation 19), also known as B-Lymphocyte Surface Antigen B4 and CVID3, is a transmembrane protein expressed in follicular dendritic cells and all B lineage cells except plasma cells. CD19 plays two major roles in human B cells. It acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane and it works within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Due to its presence on all B cells, it is a biomarker for B lymphocyte development and lymphoma diagnosis and can be used as a target for leukemia immunotherapies. CD19-targeted therapies based on T cells that express CD19-specific chimeric antigen receptors (CARs) have been utilized for their antitumor abilities in patients with CD19+ lymphoma and leukemia, such as Non-Hodgkins Lymphoma (NHL), CLL (chronic lymphocytic leukemia) and ALL (acute lymphoblastic leukemia). The T cell-specific receptor CD28 is an important regulator of the immune system. The ligation of CD28 and its ligands CD80/CD86 on the APC provides a critical costimulatory signal alongside T cell receptor (TCR) for T cell activation. The costimulatory signal can also be delivered by the interaction between CD28 and its agonist antibody. The use of bispecifics targeting these proteins can result in improved T cell cytotoxicity.
Description: RG-6333 is a bispecific agonist that targets CD19 and CD28. It specifically recognizes and binds to the CD19 antigen on the surface of B-cell malignancies to locate tumor cells. RG-6333 activates T cells by binding to CD28 overcoming activation barriers to enhance anti-tumor immunity.
Purity: ≥90%
Reconstitution: The product can be reconstituted/diluted with sterile PBS or saline.
Storage Stability: At least 6 months at -80°C.
Target: CD19, CD28
Uniprot: P11609 and P31041
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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