Clone Name: SPTBN2/1778
Light Chain: Kappa
Application Note: WB: 1-2μg/ml. ICC/IF: 1-2μg/ml. IHC-P: 1-2μg/ml for 30 minutes at RT. ELISA: 2-4μg/ml (for coating). *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 271
Form: Liquid
Buffer (with preservative): 10mM PBS, 0.05% BSA, 0.05% Sodium azide.
Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Background: Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]
Uniprot ID: O15020
Antigen Species: Human
Immunogen: Recombinant fragment (around aa356-475) of human SPTBN2 protein (exact sequence is proprietary)
Purification: Protein A/G purified
Conjugation: Unconjugated
Full Name: spectrin beta, non-erythrocytic 2
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