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Application: Useful for ELISA-based assays.
Background: TL1A is involved in immune regulation by binding to two receptors of the TNF (Tumor Necrosis Factor) family present in T and NK cells: DR3 and DcR3. Soluble TL1A induces CD4+ T cell proliferation and cytokine secretion. TL1A bound to DR3 can switch immune response towards type 1 T-helper cells. Dysregulation can lead to pathologies such as inflammatory bowel disease (IBD) and other auto-immune diseases. TL1A is thus an attractive target for auto-immune disease treatment. Tulisokibart (PRA023) is a humanized IgG1-κ monoclonal antibody. Tulisokibart targets to TNFSF15/TL1A. Tulisokibart can be used to study a variety of inflammatory/fibrotic diseases, such as Crohn's Disease (CD) and ulcerative colitis.
Biological Activity: Loaded Tulisokibart on AHC2 biosensor, can bind TL1A/TNFSF15 Protein, Human (HY-P71913) with an affinity constant of 3.693E-10 M as determined in BLI assay.
CAS Number: 1874157-95-5
Description: Tulisokibart (PRA023) is a humanized IgG1-κ monoclonal antibody. Tulisokibart targets to TNFSF15/TL1A. Tulisokibart can be used to study a variety of inflammatory/fibrotic diseases, such as Crohn's Disease (CD) and ulcerative colitis.
Format: Aqueous buffer solution.
Formulation: Supplied as a 0.22 μm filtered solution in 100 mM Pro-Ac, 20 mM Arg, pH 5.0.
Purity: ≥90% by SEC-HPLC
Reconstitution: The product can be reconstituted/diluted with sterile PBS or saline.
Storage Stability: Store at -80°C for 2 years. Aliquots should be stored at the same temperature after first use to avoid multiple freeze-thaws.
Target: TL1A
Uniprot: O95150
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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